The designer used her iconic aesthetic to craft clothing, home accessories, and, perhaps most famously, handbags.
She is survived by daughter Frances and her husband Andy Spade, whom she wed in 1994.
Following the news of her death, celebrities took to social media to express their condolences. Many shared their own experiences with Spade and her iconic designs. Click through to read the messages shared in the wake of Spade's death.
If you are thinking about suicide, please call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255) or the Suicide Crisis Line at 1-800-784-2433.