Over 6 million people were advised to evacuate from Florida, the largest mass evacuation in history.
The category 4 storm has touched down in the Florida Keys, as one-third of the state's residents hunker down for the worst to come.
As of 8:30 a.m. Sunday morning, over a million residents and businesses were without power. In Miami-Dade County, more than 456,000 people lost power.
As the rest of the nation awaits the outcome of one of the most powerful Atlantic hurricanes on record, there are a number of opportunities to help out.
Here's how you can help:
The American Red Cross needs volunteers in Puerto Rico, Florida, Georgia, North and South Carolina, and Virginia.
According to ABC News, some local shelters are also taking volunteers. You can apply through the Volunteer Florida website.
Airbnb hosts have opened up their homes to hurricane Irma evacuees for free. If you can to offer a free room, be sure to sign up.
Those without cell phone reception during or after the storm can download Zello, a walkie talkie-like app that will allow them to communicate.. The app is a free download.
UNICEF is providing emergency relief and will help children affected by the hurricane resume their education in the coming months.
The crowdfunding website GlobalGiving wants to raise $2 million for relief and recovery efforts in regions affected by the hurricane.
The National Voluntary Organizations Active in Disaster is registering volunteers to help in Puerto Rico, the U.S. Virgin Islands, and other areas affected by Hurricane Irma.
SPCA International provides support to shelters and rescue groups working with animals affected by natural disasters.
GoFundMe has created a centralized landing page which aggregates all campaigns created by and for Florida victims in need.