Over 6 million people were advised to evacuate from Florida, the largest mass evacuation in history.
The category 4 storm has touched down in the Florida Keys, as one-third of the state's residents hunker down for the worst to come.
As of 8:30 a.m. Sunday morning, over a million residents and businesses were without power. In Miami-Dade County, more than 456,000 people lost power.
Here's how you can help:
SPCA International provides support to shelters and rescue groups working with animals affected by natural disasters.