When it comes to choosing a lube, it's all about personal preference. "In general," Dr. Hoskins says, "silicone-based lubes are more body-friendly because they last longer, which means they won't evaporate, causing cell damage." However, silicone-based lubes are harder to wash off, and you can't use them with silicone sex toys — it'll break down the material. Water-based lubricant feels less sticky than silicone, and it doesn't last as long because it evaporates. Because it has less staying power, Dr. Hoskins says it's best to not use it for anal sex: "It may be associated with an increased rate of damage to cells, and therefore increase chances of HIV transmission." Water-based lube is also not ideal for use in water, though it does wash off more easily. Dr. Hoskins says some patients report that silicone lube irritates their skin, so again, it's all about finding what works best for your body.