A statement from his office, given to the New York Times, indicates he passed at 4:28 p.m., following his decision to discontinue medial treatment for brain cancer. His wife, Cindy McCain, wrote on Twitter of his passing, "My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best."
His daughter, Meghan McCain, eulogised him on Twitter, writing in part, "My father's passing comes with great sorrow and grief for me, for my mother, for my brothers, and for my sisters. He was a great fire who burned bright and we lived in his light and warmth for so very long. We know that his flame lives on, in each of us. The days and years to come will not be the same without my dad – but they will good days, filled with life and love, because of the example he lived for us."
When the decision was announced, an official statement said: "Our family is immensely grateful for the support and kindness of all his caregivers over the last year, and for the continuing outpouring of concern and affection from John’s many friends and associates, and the many thousands of people who are keeping him in their prayers."
In a statement, former President Barack Obama, who ran against McCain in the 2008 election, wrote in part, "Few have been tested the way John once was, or required to show the kind of courage that he did. But all of us can aspire to the courage to put the greater good above our own. At John's best, he showed us what that means. And for that, we are all in his debt."
McCain was born on August 29, 1936 at the the Coco Solo Naval Station in Panama. In 1954, he enrolled at the U.S. Naval Academy, graduating in 1958. McCain fought in the Vietnam War, where he was captured and kept prisoner in North Vietnam between 1967 and 1973.
After his release, he returned to the United States and retired from the Navy in 1981. The naval honours he received for his service include the Silver Star, Bronze Star, Legion of Merit, Purple Heart, and the Distinguished Flying Cross.
The Arizona Republican was elected to the U.S. House of Representatives in 1982 and after serving two terms, to the U.S. Senate in 1986. Through his career as a lawmaker, he was known as a "maverick" for being willing to disagree with the Republican party on the occasions he saw fit. He ran for president in 1999 and again during the 2008 presidential election, when he successfully earned the Republican nomination. However, he lost in the general election to President Barack Obama.
McCain's long career has left an indelible mark in the country, but he truly soldiered on in the last 18 months. He has repeatedly criticised President Donald Trump for his close relationship to Russian President Vladimir Putin and helped stop the repeal of the Affordable Care Act.
McCain was diagnosed with glioblastoma, an aggressive type of brain cancer, last summer. Despite his illness and the intense treatment to combat it, he returned to the Senate for some key votes in 2017. He didn't return to vote in 2018, however. His family announced in late August that he was choosing to discontinue the treatment.
In the memoir, McCain adds his own response: "And I do too. I hate to leave it. But I don't have a complaint. Not one. It's been quite a ride...I made a small place for myself in the story of America and the history of my times."
McCain is survived by his mother Roberta McCain, his wife Cindy, and his seven children: Douglas, Andrew, Sidney, Meghan, John, James, and Bridget. May he rest in peace.