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Switched At Birth (2011-2017)
The teen drama about two high school girls who discover they were switched at birth features a main character with severe hearing loss (Daphne, one of the switched kids), and several recurring characters with other disabilities throughout its run. Over the course of the show, they tackled the challenges deaf kids face in mainstream schools, the frustration of well-meaning hearing people trying to speak for them rather than allowing deaf people to be their own advocates, and even featured an entire episode in ASL.
Though Roland (played by Macaulay Culkin) often uses his disability as a punchline, the film does explore his need to be independent as someone in a wheelchair.
Glee didn't always handle all subjects with grace, but there were multiple episodes that really examined Artie's dueling feelings of isolation and empowerment.
The Theory of Everything (2014)
Though Stephen Hawking was already an incredibly well-known figure before the release of this biopic, the movie offered a glimpse not only into the world of someone dealing with a degenerative disease, but how his disability effected his loved ones.
The West Wing (1999-2006)
In early episodes, President Bartlet's MS was mostly present as a secret (or later, as a scandal). But as the disease progressed, the show began to examine how someone, even with all the assistance in the world, could struggle to do their job while dealing with a disability.