"Merlex," as fans have taken to calling them, would makes sense. It's a logical next step for the two pals to go considering all the memories they've shared, but what does Justin Chambers, who plays one half of the rumored couple opposite Ellen Pompeo, think of all this speculation?
However, he's not gunning for it to happen any time soon.
"I’m very comfortable with them being platonic — like brother and sister, and friends," he continued. "I think that suits them better."
He argues that their friendship has lasted so long it would be difficult to transition to something new.
"Alex and [Meredith] have come up together and I don’t know, [it’d be] a little weird," he said. "But anything is possible.”
However, his reservations don't mean he's dead set on their friendship. After all, he has some experience with this exact phenomenon IRL.
"Nobody knows how things go, you know?" he added. "I was friends with my wife before we started dating."
And then there's his character's ex, Jo Wilson (played by Camilla Luddington), to think about.
"I’m excited to see what happens with him and 'Jolex," Chambers said, referring to their ship name. "I think they really love each other. I know they have a lot of obstacles to go through but it will be interesting to see what conflicts, fires they can put out."
We'll have to keep watching to find out which love — ex or friendship — is stronger.