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Star Wars (1977)
Leia (Carrie Fisher) and Luke (Mark Hamill) don't share bone structure, eye color, skin color, hair color, or temperament. They'd never be mistaken for twins by anyone who saw them, which maybe makes this scene a little less nauseating, but not by much.
Watch Star Wars on Amazon.
Ferris Bueller's Day Off (1986)
Jeannie (Jennifer Grey) clearly despises her older brother Ferris (Matthew Broderick), and would probably really love to discover the reason they look nothing alike is because she's adopted. We can quickly dismiss their dissimilar appearance because, duh, no one else could play those roles and John Hughes' casting decisions must never be questioned.
Watch Ferris Bueller's Day Off on Netflix.
Parenthood (movie 1989, series 2010-2015)
Neither the movie's Buckman siblings (Steve Martin, Dianne Wiest, Harley Kozak, and Tom Hulce), nor the TV show's Bravermans (Peter Krause, Lauren Graham, Dax Shepard, and Erika Christensen) bear any resemblance to each other. That's okay, because what unites them is not really their shared experiences growing up, but their shared struggles in raising their own kids now.
Watch Parenthood the movie on Amazon.
Little Women (1994)
The whole point of this story is how Meg (Trini Alvarado), Jo (Winona Ryder), Beth (Claire Danes), and Amy (Kirsten Dunst/Samantha Mathis), have totally disparate temperaments and follow the paths that best suit them. Maybe it's best that they also don't resemble each other in the least.
Watch Little Women on Amazon.
Dark hair is about all Monica (Courteney Cox) and Ross (David Schwimmer) share genetically. The universe in which the girl sibling gets perfect features, while her brother gets the goofy ones would be a fair one we don't see in reality. And yet, their mismatched personalities and bickering remind us what true siblinghood is all about.
Watch Friends on Netflix.