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Liz Lemon — 30 Rock (2006-2013)
Liz made the kind of defeated-by-stress cries of distress you only wish you could make. And her anxiety was warranted; trying to have it all is tough. But when stress turns you into a Gollum-like monster, it's time to take a yoga class.
Ben Wyatt — Parks and Rec (2009-2015)
Chris or Andy high on morphine wouldn't have been nearly as funny, because they were already high on life (and possibly helium and bee pollen, respectively). But seeing a super-chill Ben — whose stressors included his loved ones, the police force, and ice — is hysterical.
Niles Crane — Frasier (1993-2004)
When anything could be dangerous (a dirty spoon, a public chair that hasn't been properly sanitized, a very athletic lover of your ex-wife), stress is naturally going to pile on. The trick is lighting a lavender-scented candle before you get to the spontaneous-public-nudity phase.
Rory Gilmore — Gilmore Girls (2000-2007)
Not even Rory's many lists can reduce her stress. But she's even more undone when she no longer has all the things to do. Some people's base level is stress, and it's best not to disrupt that.