Several big-name stars stopped by the E! show for a final sendoff. After seven years, Handler is moving on to host a new program on Netflix.
Among the evening's most memorable moments? Ellen DeGeneres confronting a butt-naked Handler about never being invited on as a guest. This then prompted Handler to joke about being a lesbian who sits in bed watching Orange Is The New Black. Not to generalize or anything.
"We love you Chelsea, but you have to get your head out of your ass," Bullock cracked. "You have to get it out of your vagina. You're not funny. You're not cool. I think you're probably one of the most unhip people I've ever met."
It's hard to top a performance from Miley Cyrus and a sing-along farewell from the likes of Gwen Stefani, Gerard Butler, Dave Grohl, and Alanis Morisette, but one man was up to the task: former Handler paramour 50 Cent.
The rapper, who Handler dated in 2010 (a relationship that ended after a huge fight), showed up for his own performance. Fiddy's cameo proves there are no hard feelings.