From what we can gather, the premise is that Seth MacFarlane's character learns that the Old West is actually a pretty crappy place to live — what with all the famine, wild animals, shoot-outs, and neighborhood drunks. He's joined by a pretty impressive group of actors, including Charlize Theron, Liam Neeson, Amanda Seyfried, and Neil Patrick Harris. They all dress up in vests and plaid and tromp around on a fake western set while cracking dirty jokes. But, we won't spoil anything else.
Watch the trailer for yourself, and then see the flick in its entirety this May. If you're brave enough, that is.