"HPV can act like a tornado hitting the genome, disrupting and rearranging nearby host-cell genes," says David Symer, MD, PhD, one of the coauthors of the study. Researchers observed the ways that the HPV virus actually inserted itself into human DNA — effectively disrupting the normal functioning of the cells it invaded.
These changes produced cancer in a couple of different ways — either by causing overproduction of cancer-causing genes or the disruption and silencing of cancer-suppressing genes. This new research offers scientists an important window into the mechanism by which HPV — and possibly other viruses — cause disease. And, it highlights the importance in developing and promoting vaccines that can stop HPV before it even starts. (Eureka Alert)